FGFR1/D8Z2
Alternative name:
FISH Eosinophilia probe
Methodology
FISH
Test Description and clinical significance
Probes
FGFR1/D8Z2 (8p12/8p11.1-q11.1)
Disease:
Myeloproliferative neoplasm, Osteoglophonic Dysplasia, squamous cell carcinoma of the lung, breast, esophagus, thymus, and other locations, encephalocraniocutaneous lipomatosis (ECCL), Hartsfield syndrome, Kallmann syndrome, Pfeiffer syndrome
Fibroblast growth factor receptor 1 (FGFR1) is a receptor tyrosine kinase. FGFR1 overexpression or amplification in squamous cell carcinoma is associated with tumor growth. Studies have shown overexpression or amplification of FGFR1 to be vulnerable to FGFR-tyrosine kinase inhibitors and FGFR1 inhibitors maybe a promising therapeutic option and have shown tumors with FGFR1 amplification may be sensitive to FGFR1 tyrosine kinase inhibitors. Amplification of the FGFR1 gene is also associated with a poorer prognosis and likelihood of metastasis for some cancers
Specimen Requirements
Collection:
1~2ml in Green top (Sodium Heparin) tube OR Lavender top (EDTA) tube.
Stability:
120 Hours
Unacceptable Conditions:
DO NOT FREEZE
Storage & Transport
Room Temperature
CPT(s)
88377
New York Approved
YES
TAT
2 Days
*The CPT codes provided are for informational purposes only and are based on AMA guidelines The billing party is solely responsible for correct CPT coding.
