siParadigm - Trusted oncology diagnostic informatics

Disease-Focused Next Generation Sequencing (NGS)

Testing for somatic (acquired) gene mutations can help better understand a range of blood and solid tumor cancers. While insights continue to uncover new gene associations and their impact across the continuum of patient care, especially in treatment selection, siParadigm provides panels that deliver the most actionable and relevant information for clinicians.

Solid Tumor Panels

Oncomine™ Focus Panel (52 Genes)

*Hotspot Genes (35)*				*CNVs (19)*		*Fusion Driver Genes (23)*
*AKT1*	*ERBB4*	*JAK2*	*PIK3CA*	*ALK*	*FGFR3*	*ABL1*	*ETV5*	*RAF1*
*ALK*	*ESR1*	*JAK3*	*RAF1*	AR	*FGFR4*	*ALK*	*FGFR1*	*RET*
AR	*FGFR2*	*KIT*	*RET*	*BRAF*	*KIT*	*AKT3*	*FGFR2*	*ROS1*
*BRAF*	*FGFR3*	*KRAS*	*ROS1*	*CCND1*	*KRAS*	*AXL*	*FGFR3*
*CDK4*	*GNA11*	*MAP2K1*	*SMO*	*CDK4*	*MET*	*BRAF*	*MET*
*CTNNB1*	*GNAQ*	*MAP2K2*		*CDK6*	*MYC*	*EGFR*	*NTRK1*
*DDR2*	*HRAS*	*MET*		*EGFR*	*MYCN*	*ERBB2*	*NTRK2*
*EGFR*	*IDH1*	*MTOR*		*ERBB2*	*PDGFRA*	*ERG*	*NTRK3*
*ERBB2*	*IDH2*	*NRAS*		*FGFR1*	*PIK3CA*	*ETV1*	*PDGFRA*
*ERBB3*	*JAK1*	*PDGFRA*		*FGFR2*		*ETV4*	*PPARG*

Turn Around Time (TAT): 7 – 10 days
Specimen Requirement: FFPE blocks, tissue sections or extracted DNA and RNA are acceptable.
In case of FFPE sections, 5-10 sections are recommended.
Previously extracted DNA is acceptable when transported on ice and RNA on dry ice. A minimum of 20 μl of each DNA and RNA with a concentration of at least 5ng/μl and an OD260/280 ratio of 1.7-1.9 and 2.0-2.1 respectively, obtained on a spectrophotometer is required.

NSCLC and CRC NGS Panel (22 Genes)

ALK

AKT1

BRAF

CTNNB1

DDR2

EGFR

ERBB2

ERBB4

FBX7

FGFR1

FGFR2

FGFR3

KRAS-Extended

MAP2K1

MET

NOTCH1

NRAS

PTEN

PIK3CA

STKI1

SMAD4

TP53

Hematology Panels

Myeloid Focused, DNA

ABL1

* ASXL1

* BCOR

BCORL1

BRAF

* CALR

CBL

* CEBPA

CSF3R

CXCR4

DDX41

DNMT3A

* ETV6

* EZH2

FLT3

GATA1

GATA2

HRAS

IDH1

IDH2

* IKZF1

JAK2

KIT

KRAS

MPL

MYD88

* NF1

NOTCH1

NPM1

NRAS

* PHF6

PIGA

PPM1D

* PRPF8

PTPN11

* RB1

* RUNX1

SETBP1

SF3B1

* SH2B3

SRSF2

* STAG2

STAT3

STAT5B

* TET2

* TP53

U2AF1

WT1

* ZRSR2

* Indicates full genes (17)

Myeloid Comprehensive, DNA

ABL1

ANKRD26

* ASXL1

* BCOR

BCORL1

BRAF

* CALR

CBL

CBLB

CBLC

CDKN2A

* CEBPA

CSF3R

CUX1

CXCR4

DDX41

DNMT3A

ETNK1

* ETV6

* EZH2

FBXW7

FLT3

GATA1

GATA2

GNAS

GNB1

HRAS

IDH1

IDH2

* IKZF1

IL7R

JAK1

JAK2

JAK3

KIT

KRAS

MPL

MYD88

* NF1

NOTCH1

NPM1

NRAS

PAX5

* PHF6

PIGA

PPM1D

* PRPF8

PTEN

PTPN11

* RB1

* RUNX1

SETBP1

SF3A1

SF3B1

* SH2B3

SMARCB1

SMC1A

SMC3

SRSF2

* STAG2

STAT3

STAT5B

* TET2

* TP53

U2AF1

U2AF2

UBA1

WT1

XPO1

* ZRSR2

* Indicates full genes (17)

AML/Eosinophilia, DNA/RNA

* ABL1

* ALK

ANKRD26

ASXL1

* BCL2

BCOR

* BRAF

CALR

CBL

* CCND1

CEBPA

* CREBBP

CSF3R

DDX41

DNMT3A

* EGFR

* ETV6

EZH2

* FGFR1

* FGFR2

FLT3

* FUS

GATA2

* HMGA2

HRAS

IDH1

IDH2

IKZF1

* JAK2

KIT

* KMT2A

(MLL)

KRAS

* MET

* MECOM

* MLLT10

* MLLT3

MPL

* MYBL1

MYD88

* MYH11

NF1

NPM1

NRAS

* NTRK3

* NUP214

* NUP98

* PDGFRA

* PDGFRB

PHF6

PPM1D

PRPF8

PTPN11

* RARA

RB1

* RBM15

* RUNX1

SETBP1

SF3B1

SH2B3

SMC1A

SMC3

SRSF2

STAG2

* TCF3

TET2

* TFE3

TP53

U2AF1

WT1

ZRSR2

* Indicates fusion driver genes (30)

Lymphoid

* ATM

B2M

BCL2

* BCL6

BIRC3

BRAF

BTK

CARD11

CCND1

* CCND3

CD79B

CREBBP

CXCR4

DNMT3A

EP300

* EZH2

ETV6

FAS

FBXW7

FOXO1

GNA13

ID3

* IDH2

* IRF4

* KMT2D

MAP2K1

MYC

MYD88

NFKBIE

NOTCH1

NOTCH2

* PAX5

* PIM1

* PLCG2

PRDM1

* PTEN

* RHOA

RPS15

* SAMHD1

* SF3B1

* SOCS1

STAT3

STAT5B

STAT6

* TENT5C

* TET2

TNFAIP3

TNFRSF14

* TP53

XPO1

* Indicates genes covered full coding sequences (19)

NGS

Disease-Focused Next Generation Sequencing (NGS)

Solid Tumor Panels

Oncomine™ Focus Panel (52 Genes)

NSCLC and CRC NGS Panel (22 Genes)

Hereditary Cancer Assessment Panel

Hematology Panels

Myeloid Focused, DNA

Myeloid Comprehensive, DNA

AML/Eosinophilia, DNA/RNA

Lymphoid

"While we have many laboratories to choose from, we consider siParadigm to be the most reliable. Contact with a hematopatholgist is rapid and informative."

Discover more.

A Model Experience

Accredited and Certified