PCM1/JAK2
Alternative name:
FISH Eosinophilia probe
Methodology
FISH
Test Description and clinical significance
Probes
PCM1/JAK2 (8p22/9p24.1)
Disease:
Myeloid and lymphoid neoplasms with eosinophilia and PCM1/JAK2 translocation.
PCM: *(Pericentriolar Material)The protein encoded by this gene is a component of centriolar satellites, which are electron dense granules scattered around centrosomes. Inhibition studies show that this protein is essential for the correct localization of several centrosomal proteins, and for anchoring microtubules to the centrosome. JAK2: Janus kinase: this gene encodes a non-receptor tyrosine kinase that plays a central role in cytokine and growth factor signalling. The primary isoform of this protein has an N-terminal FERM domain that is required for erythropoietin receptor association
NGS MPN panel is recommended
Specimen Requirements
Collection:
1~2ml in Green top (Sodium Heparin) tube OR Lavender top (EDTA) tube.
Stability:
120 Hours
Unacceptable Conditions:
DO NOT FREEZE
Storage & Transport
Room Temperature
CPT(s)
88377
New York Approved
YES
TAT
2 Days
*The CPT codes provided are for informational purposes only and are based on AMA guidelines The billing party is solely responsible for correct CPT coding.
