Brain Cancer FISH Panel
Methodology
FISH
Test Description and clinical significance
Probes
(1p36.31/1q25.3 & 19p13.3/19q13.32-q13.33 & 10q23.2-q23.31/10p11.1-q11.1)
Disease:
Brain cancer
Deletions of the 1p36 and 19q13 region genes are seen in glial tumors. Concurrent deletion of the 1p36 and 19q13 regions are prognostic factors as they are associated with improved prognosis and responsiveness to therapy. PTEN (phosphatase and tensin homologue deleted on chromosome 10) is a tumor suppressor gene and is mutated in a large number of cancers. PTEN deletions in brain tumors are common and related to poor prognosis.
Specimen Requirements
Collection:
FFPET/un-stained slides
Stability:
Indefinitely
Unacceptable Conditions:
Unlabeled specimen/Decalcified tissue/Insuffcient tissue fixation
Storage & Transport
Room Temperature
CPT(s)
88377x3
New York Approved
YES
TAT
3 Days
*The CPT codes provided are for informational purposes only and are based on AMA guidelines The billing party is solely responsible for correct CPT coding.
