KMT2A
Alternative name:
Mixed-lineage leukemia (MLL)
Methodology
FISH
Test Description and clinical significance
Probes
11q23.3
Disease:
Wiedemann-Steiner Syndrome and AML with t(9;11), ALL
This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Patients with KMT2A-rearranged ALL have a poor prognosis
BCR/ABL p190 Minor by PCR & NGS-AML panel are recommended
Specimen Requirements
Collection:
1~2ml in Green top (Sodium Heparin) tube OR Lavender top (EDTA) tube. 10 mL of fluid in RPMI medium, or
1 cm3 marble-sized piece of fresh tumor immersed completely with RPMI medium or sterile saline.
Stability:
120 Hours/48 hours
Unacceptable Conditions:
DO NOT FREEZE
Storage & Transport
Room Temperature/Refrigerated (2–8°C )
CPT(s)
88377
New York Approved
YES
TAT
2 Days
*The CPT codes provided are for informational purposes only and are based on AMA guidelines The billing party is solely responsible for correct CPT coding.
