ABL1/BCR
Alternative name:
ABL1/BCR fusion gene, Philadelphia chromosome
Methodology
FISH
Test Description and clinical significance
Probes
9q34.11-q34.13/22q11.22-q11.23
Disease:
CML, some ALL and AML (rarely).
ABL1/BCR fusion gene is mainly caused by the t(9; 22)(q34; q11.2) translocation, which results in the Philadelphia chromosome. It is the hallmark in chronic myeloid leukemia (CML), but can also be present in acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML), MPD, MDS. It is a useful prognostic factor.
BCR/ABL p190 Minor by PCR & NGS MPN panel are recommended
Specimen Requirements
Collection:
1~2ml in Green top (Sodium Heparin) tube OR Lavender top (EDTA) tube. 10 mL of fluid in RPMI medium, or
1 cm3 marble-sized piece of fresh tumor immersed completely with RPMI medium or sterile saline.
Stability:
120 Hours/48 hours
Unacceptable Conditions:
DO NOT FREEZE
Storage & Transport
Room Temperature/Refrigerated (2–8°C )
CPT(s)
88377
New York Approved
YES
TAT
2 Days
*The CPT codes provided are for informational purposes only and are based on AMA guidelines The billing party is solely responsible for correct CPT coding.
