RUNX1T1/RUNX1
Alternative name:
AML1-ETO
Methodology
FISH
Test Description and clinical significance
Probes
8q21.3-q22.1/21q22.11-q22.12
Disease:
AML, RUNX1 familial platelet disorder with associated myeloid malignancies (RUNX1-FPDMM), MDS
RUNX1 is a transcription factor that forms a complex with the cofactor CBFB. This complex provides stability to the RUNX1 protein which is involved in the generation of hematopoietic stem cells and for their differentiation into myeloid and lymphoid lines. Important in classifying hematopoietic malignancies.
NGS-AML panel is recommended
Specimen Requirements
Collection:
1~2ml in Green top (Sodium Heparin) tube OR Lavender top (EDTA) tube.
Stability:
120 Hours
Unacceptable Conditions:
DO NOT FREEZE
Storage & Transport
Room Temperature
CPT(s)
88377
New York Approved
YES
TAT
2 Days
*The CPT codes provided are for informational purposes only and are based on AMA guidelines The billing party is solely responsible for correct CPT coding.
