Actin (Smooth Muscle) (SMA)
Alternative name:
Smooth Muscle Actin
Methodology
Immunohistochemistry (IHC)
Test Description and clinical significance
Disease:
smooth muscle tumors
SMA is a sensitive marker of myoepithelial differentiation, but it is not specific, because any cell with substantial expression of actin is positive for SMA. It stains the muscularis propria and muscularis mucosae of the gastrointestinal tract, the uterine myometrium, medial layer of blood vessels, myoepithelial cells of salivary glands and other organs. The antibody does not stain skeletal and cardiac muscle, endothelium, connective tissue, epithelium or nerve. The antibody can be used to identify smooth muscle tumors (leiomyomas and leiomyosarcomas).
Specimen Requirements
Collection:
FFPE/un-stained slides/Fresh tissue in formalin
Stability:
Room temperature
Unacceptable Conditions:
Unlabeled specimen/specimen left unfixed
for extended periods
Storage & Transport
Room Temperature
CPT(s)
88342 if initial single stain or 88341 for each additional stain Actin (smooth muscle)
New York Approved
NO
TAT
1 Day
*The CPT codes provided are for informational purposes only and are based on AMA guidelines The billing party is solely responsible for correct CPT coding.
