BCL2
Methodology
Immunohistochemistry (IHC)
Test Description and clinical significance
Disease:
Lymphoma (folicular, Diffuse Large Cell Lymphoma), bone cancer and stomach cancer.
BCL-2 (B-cell lymphoma 2), encoded in humans by the BCL2 gene, is the founding member of the BCL-2 family of regulator proteins that regulate cell death (apoptosis), by either inhibiting (anti-apoptotic) or inducing (pro-apoptotic) apoptosis. The over-expression of the anti-apoptotic Bcl-2 protein in lymphocytes alone does not cause cancer. But simultaneous over-expression of BCL-2 and the proto-oncogene myc may produce aggressive B-cell malignancies including lymphoma.
Specimen Requirements
Collection:
FFPE/un-stained slides/Fresh tissue in formalin
Stability:
Room temperature
Unacceptable Conditions:
Unlabeled specimen/specimen left unfixed
for extended periods
Storage & Transport
Room Temperature
CPT(s)
88342 if intial single stain or 88341 for each additional stain. BCL-2
New York Approved
NO
TAT
1 Day
*The CPT codes provided are for informational purposes only and are based on AMA guidelines The billing party is solely responsible for correct CPT coding.
