Beta-Catenin
Methodology
Immunohistochemistry (IHC)
Test Description and clinical significance
Disease:
Colorectal cancer resulting from familial adenomatous polyposis (FAP)
The IHC Beta Catenin test is a test that is used to detect mutations in the gene Beta Catenin. Beta Catenin is a protein that helps in the generation, development and differentiation of cells. It also helps in cell adhesion and the development of the embryo. When there are alterations in beta-catenin degradation, it accumulates to a sufficient extent to be detected in the nuclei of tumor cells immunohistochemically, a feature that can be exploited in the differential diagnosis of selected neoplasms.
Specimen Requirements
Collection:
FFPE/un-stained slides/Fresh tissue in formalin
Stability:
Room temperature
Unacceptable Conditions:
Unlabeled specimen/specimen left unfixed
for extended periods
Storage & Transport
Room Temperature
CPT(s)
88342 if intial single stain or 88341 for each additional stain. Beta-Catenin
New York Approved
NO
TAT
1 Day
*The CPT codes provided are for informational purposes only and are based on AMA guidelines The billing party is solely responsible for correct CPT coding.
