BRAF by IHC
Methodology
Immunohistochemistry (IHC)
Test Description and clinical significance
Disease:
Hairy Cell Leukemia, melanoma, thyroid cancer, lung cancer, NHL, langerhans cell histiocytosis (LCH)
Serine/threonine-protein kinase B-Raf (BRAF) is a cytoplasmic serine-threonine kinase of the RAF family which mediates downstream cellular responses to growth signals through the mitogen-activated protein kinase (MAPK) signaling pathway. Oncogenic mutations in the BRAF gene constitutively activate the MAPK signaling pathway and result in increased cell proliferation and apoptosis resistance.
Specimen Requirements
Collection:
FFPE/un-stained slides/Fresh tissue in formalin
Stability:
Room temperature
Unacceptable Conditions:
Unlabeled specimen/specimen left unfixed
for extended periods
Storage & Transport
Room Temperature
CPT(s)
88342 if intial single stain or 88341 for each additional stain BRAF
New York Approved
NO
TAT
1 Day
*The CPT codes provided are for informational purposes only and are based on AMA guidelines The billing party is solely responsible for correct CPT coding.
