CD117(C-KIT)
Methodology
Immunohistochemistry (IHC)
Test Description and clinical significance
Disease:
Gastrointestinal Stromal Tumors (GISTs), mast cell diseases, acute myeloid leukemia (AML), small cell lung carcinoma (SCLC), and Ewing's sarcoma, melanoma
KIT is a cytokine receptor expressed on the surface of hematopoietic stem cells as well as other cell types. Altered forms of this receptor may be associated with some types of cancer. KIT is a receptor tyrosine kinase type III, which binds to stem cell factor. Testing for CD117/c-kit expression may be a useful tool for the identification of several malignant neoplasmas. It can also assist in both diagnosis and the prediction of drug sensitivity to tyrosine kinase inhibitor STI571 treatment.
Specimen Requirements
Collection:
FFPE/un-stained slides/Fresh tissue in formalin
Stability:
Room temperature
Unacceptable Conditions:
Unlabeled specimen/specimen left unfixed
for extended periods
Storage & Transport
Room Temperature
CPT(s)
88342 if intial single stain or
88341 for each additional stain
New York Approved
NO
TAT
1 Day
*The CPT codes provided are for informational purposes only and are based on AMA guidelines The billing party is solely responsible for correct CPT coding.
