CD21
Methodology
Immunohistochemistry (IHC)
Test Description and clinical significance
Disease:
Follicular, mantle cell lymphomas, and mature leukemias
CD21 antigen is a type I integral membrane glycoprotein which functions as the receptor for the C3d fragment of the third complement component. The CD21 molecule, present on mature B cells, is involved in transmitting growth-promoting signals to the interior of the B cell and acts as a receptor for Epstein-Barr virus. CD21 antigen is reported to be found in B cell chronic lymphocytic leukemias and in a subset of T cell acute lymphocytic leukemias but is absent on T lymphocytes, monocytes and granulocytes. CD21 antigen is also reported to be expressed in follicular dendritic cells and in follicular and mantle cell lymphomas, mature leukemias and lymphomas.
Specimen Requirements
Collection:
FFPE/un-stained slides/Fresh tissue in formalin
Stability:
Room temperature
Unacceptable Conditions:
Unlabeled specimen/specimen left unfixed
for extended periods
Storage & Transport
Room Temperature
CPT(s)
88342 if intial single stain or 88341 for each additional stain. CD21
New York Approved
NO
TAT
1 Day
*The CPT codes provided are for informational purposes only and are based on AMA guidelines The billing party is solely responsible for correct CPT coding.
