CD31
Methodology
Immunohistochemistry (IHC)
Test Description and clinical significance
Disease:
Angiomas, angiosarcomas, and small lymphocytic and lymphoblastic lymphomas
CD31 is a transmembrane protein encoded by the PECAM1 (platelet endothelial cell adhesion molecule) gene. CD31 has essential roles in platelet biology, signal transduction, as well as leukocyte and endothelial cell biology. CD31 is positive in more than 90% of angiosarcomas, and the staining pattern is distinct and membranous, in contrast to the weak cytoplasmic staining reported in a small number of adenocarcinomas and mesotheliomas. CD31 is also used to identify vascular invasion and assess the micro-vessel density of tumors.
Specimen Requirements
Collection:
FFPE/un-stained slides/Fresh tissue in formalin
Stability:
Room temperature
Unacceptable Conditions:
Unlabeled specimen/specimen left unfixed
for extended periods
Storage & Transport
Room Temperature
CPT(s)
88342 if intial single stain or 88341 for each additional stain. CD31
New York Approved
NO
TAT
1 Day
*The CPT codes provided are for informational purposes only and are based on AMA guidelines The billing party is solely responsible for correct CPT coding.
