CD34
Methodology
Immunohistochemistry (IHC)
Test Description and clinical significance
Disease:
Acute myeloid leukemia (AML), Acute lymphoblastic leukemia (ALL), Gastrointestinal stromal tumor (GIST), dermatofibrosarcoma protuberans, solitary fibrous tumor, and sarcomas.
CD34 is a single-chain transmembrane protein of approximately 116 kDa. CD34 is expressed on immature haematopoietic stem/progenitor cells, capillary endothelial cells, embryonic fibroblasts and rare glial cells in nervous tissue. Approximately 60% of acute B lymphoid leukaemias and 40% of acute myeloid leukaemias (AML), and 1% to 5% of acute T-lymphoid leukaemias express CD34. Chronic lymphoid leukaemias, lymphomas and multiple myelomas have been found to be uniformly CD34 negative.
Specimen Requirements
Collection:
FFPE/un-stained slides/Fresh tissue in formalin
Stability:
Room temperature
Unacceptable Conditions:
Unlabeled specimen/specimen left unfixed
for extended periods
Storage & Transport
Room Temperature
CPT(s)
88342 if intial single stain or 88341 for each additional stain. CD34
New York Approved
NO
TAT
1 Day
*The CPT codes provided are for informational purposes only and are based on AMA guidelines The billing party is solely responsible for correct CPT coding.
