CD68
Methodology
Immunohistochemistry (IHC)
Test Description and clinical significance
Disease:
Histiocytic malignancies are usually CD68 positive. Histiocytic sarcoma
Myeloid/monocytic sarcoma, differential diagnosis between cellular fibrous histiocytoma (83% KP1 positive) and dermatofibrosarcoma protuberans (6% KP1 positive), primary cutaneous acral CD8 positive T cell lymphoproliferative disorder.
Double staining of CD68 and CD31 can aid in the diagnosis of antibody mediated rejection by labeling intracapillary macrophages
Mucin rich transmembrane glycoprotein (110 kDa), encoded by a gene on chromosome 17p13
CD68 primarily localizes to lysosomes and endosomes; a smaller fraction circulates to the cell surface
Macrophage CD68 is upregulated in response to inflammatory stimuli
CD68 can bind apoptotic cells, phosphatidylserine and oxidized low density lipoprotein
Specimen Requirements
Collection:
FFPE/un-stained slides/Fresh tissue in formalin
Stability:
Room temperature
Unacceptable Conditions:
Unlabeled specimen/specimen left unfixed
for extended periods
Storage & Transport
Room Temperature
CPT(s)
88342 if intial single stain or 88341 for each additional stain CD68
New York Approved
NO
TAT
1 Day
*The CPT codes provided are for informational purposes only and are based on AMA guidelines The billing party is solely responsible for correct CPT coding.
