Disease:
Identifying erythroid precursors in red blood cell hypoplasia and hyperplasia, with or without dyspoietic features, breast cancers and squamous cell carcinomas of the esophagus

CD71 is an integral membrane protein that mediates the uptake of transferrin iron complexes
In human tissues, CD71 is more highly expressed in placental syncytiotrophoblast, myocytes, hepatocytes, basal keratinocytes, endocrine cells of the pancreas, spermatocytes and erythroid precursors
CD71 is present on actively proliferating cells, essential for iron transport into proliferating cells (benign and malignant)
Can be expressed by tumor cells; for example, in breast cancers and squamous cell carcinomas of the esophagus
Level of transferrin receptor is higher in early erythroid precursors during the intermediate normoblast phase, after which expression decreases through the reticulocyte phase

Collection:
FFPE/un-stained slides/Fresh tissue in formalin

Stability:
Room temperature

Unacceptable Conditions:
Unlabeled specimen/specimen left unfixed
for extended periods