Chromogranin A
Methodology
Immunohistochemistry (IHC)
Test Description and clinical significance
Disease:
Neuroendocrine tumors, and pheochromocytoma
Granin protein located in secretory vesicles of neurons and endocrine cells (Clin Invest Med 1995;18:47, Endocr Rev 2011;32:755)
Immunostain is specific but not sensitive for neuroendocrine cells; more sensitive in well differentiated versus poorly differentiated tumors
Antibody binds acidic glycoproteins in the soluble fraction of neurosecretory granules
Serum levels may not be useful for diagnosis but changes in levels may reflect response to therapy or recurrence
Specimen Requirements
Collection:
FFPE/un-stained slides/Fresh tissue in formalin
Stability:
Room temperature
Unacceptable Conditions:
Unlabeled specimen/specimen left unfixed
for extended periods
Storage & Transport
Room Temperature
CPT(s)
88342 if intial single stain or 88341 for each additional stain Chromogranin A
New York Approved
NO
TAT
1 Day
*The CPT codes provided are for informational purposes only and are based on AMA guidelines The billing party is solely responsible for correct CPT coding.
