E-Cadherin
Methodology
Immunohistochemistry (IHC)
Test Description and clinical significance
Disease:
Differentiation between lobular and ductal neoplasms of the breast, Diffuse type gastric adenocarcinoma, and Plasmacytoid urothelial carcinoma
E-cadherin is a transmembrane protein involved in cellular adhesion and polarity maintenance
E-cadherin is expressed in almost all epithelial cells
Loss of E-cadherin expression is associated with gain of tumor cell motility and invasiveness
Specimen Requirements
Collection:
FFPE/un-stained slides/Fresh tissue in formalin
Stability:
Room temperature
Unacceptable Conditions:
Unlabeled specimen/specimen left unfixed
for extended periods
Storage & Transport
Room Temperature
CPT(s)
88342 if intial single stain or 88341 for each additional stain E-Cadherin
New York Approved
NO
TAT
1 Day
*The CPT codes provided are for informational purposes only and are based on AMA guidelines The billing party is solely responsible for correct CPT coding.
