Burkitt Lymphoma FISH Panel
Methodology
FISH
Test Description and clinical significance
Probes
(9q34.11-q34.13/22q11.22-q11.23 & 8q24.21 & 8q24.21/14q32.33)
Disease:
Burkitt Lymphoma and High-Grade B-Cell Lymphoma, Multiple myeloma, B-ALL
MYC: This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. IGH: Immunoglobulins recognize foreign antigens and initiate immune responses such as phagocytosis and the complement system. MYC/IGH is a translocation that link c-myc to the immunoglobulin heavy chain locus (IgH)
Specimen Requirements
Collection:
'1~2ml in Green top (Sodium Heparin) tube OR Lavender top (EDTA) tube/ 10 mL of fluid in RPMI medium, or
1 cm3 marble-sized piece of fresh tumor immersed completely with RPMI medium or sterile saline/ FFPET block or un-stained slides'
Stability:
120 Hours/48 hours/indefinitely
Unacceptable Conditions:
DO NOT FREEZE
Storage & Transport
Room Temperature/Refrigerated (2–8°C )
CPT(s)
88377x2
New York Approved
YES
TAT
2 Days
*The CPT codes provided are for informational purposes only and are based on AMA guidelines The billing party is solely responsible for correct CPT coding.
