MiTF-1
Alternative name:
Microphthalmia Transcription Factor
Methodology
Immunohistochemistry (IHC)
Test Description and clinical significance
Disease:
Marker of melanocytic differentiation or melanin synthesis
Melanoma margins in Mohs surgery, Diagnosis of perivascular epithelioid cell tumors
Microphthalmia associated transcription factor (MITF), also known as melanocyte inducing transcription factor is a regulator of gene expression essential for melanocyte survival, development and proliferation; it also has relevance in melanoma biology and nonmelanocyte cellular functions.
MITF labels most melanocytic proliferations but is not specific for them
Specimen Requirements
Collection:
FFPE/un-stained slides/Fresh tissue in formalin
Stability:
Room temperature
Unacceptable Conditions:
Unlabeled specimen/specimen left unfixed
for extended periods
Storage & Transport
Room Temperature
CPT(s)
88342 if intial single stain or 88341 for each additional stain MiTF-1
New York Approved
NO
TAT
1 Day
*The CPT codes provided are for informational purposes only and are based on AMA guidelines The billing party is solely responsible for correct CPT coding.
