ROS1
Methodology
FISH
Test Description and clinical significance
Probes
6q22.1
Disease:
NSCLC, glioblastoma multiforme, cancers of the bile duct, ovary, stomach, colon, and rectum
It is designed to detect a chromosomal rearrangement involving the ROS1 gene located on chromosome 6q22. The ROS1 gene encodes a receptor tyrosine kinase receptor. Chromosomal rearrangements involving ROS1 have been implicated in multiple cancer indications and has been identified as an oncogenic driver in Non-small cell lung cancer. Preclinical data indicates that tumors harboring this genetic rearrangement are sensitive to Crizotinib, a ROS1 kinase inhibitor
Specimen Requirements
Collection:
FFPET/un-stained slides
Stability:
Indefinitely
Unacceptable Conditions:
Unlabeled specimen/Decalcified tissue/Insuffcient tissue fixation
Storage & Transport
Room Temperature
CPT(s)
88377
New York Approved
YES
TAT
2 Days
*The CPT codes provided are for informational purposes only and are based on AMA guidelines The billing party is solely responsible for correct CPT coding.
