FLT3 Mutation Analysis-FLT3-TKD (D835 and I836 mutations)
Unique Identifier:
ML-H002
Name on Requisition:
FLT3-TKD
Product Line:
HEME
Panel Group:
PCR
Panel Name:
FLT3-ITD & TKD by PCR
Methodology
Molecular
PCR
Test Description and clinical significance
Genes
FLT3 TKD variants (D835 and I836 mutations)
Disease:
acute myeloid leukemia
A polymerase chain reaction test aiming for detection of mutations in the FLT3 gene which are common mutations in acute myeloid leukemia (AML). This assay detects internal tandem duplication (ITD) mutations and mutations in the tyrosine kinase domain (TKD) of FLT3. Presence of these mutations in AML provide prognostic information and can aid in the determination of therapeutic regimen.
Specimen Requirements
Preparation:
PB, BM
Collection:
at least 0.5 mL EDTA, citrate (ACD) or Heparinized bone marrow and peripheral blood specimens
Stability:
96hours/4 to 7 days refrigerated
Unacceptable Conditions:
Specimen submitted is in the incorrect fixative or anticoagulant. Specimen received after the stability date. Gross hemolysis. Frozen specimen. Insufficient specimen. Unlabeled
Storage & Transport
Blood or bone marrow specimens should be kept at room temperature and preferably received within 96 hours of drawing. Samples that are 4 to 7 days old should be refrigerated.
CPT(s)
81246
TAT
3
Requisition Type
Heme
Levels of Service
Full
DexS Code
Z00XR
Prefix
MI
*The CPT codes provided are for informational purposes only and are based on AMA guidelines The billing party is solely responsible for correct CPT coding.
