CSF3R
Unique Identifier:
ML-H021
Name on Requisition:
CSF3R
Product Line:
HEME
Panel Group:
NGS
Methodology
Molecular
NGS
Test Description and clinical significance
Genes
CSF3R
Disease:
chronic neutrophilic leukemia (CNL) and atypical chronic myeloid leukemia (aCML).
Colony Stimulating Factor 3 Receptor (CSF3R) encodes the receptor for granulocyte colony-stimulating factor (G-CSF), which regulates granulocyte proliferation and differentiation. Activating and truncating mutations in CSF3R are recurrent in myeloid malignancies, particularly chronic neutrophilic leukemia (CNL) and atypical chronic myeloid leukemia (aCML). Identification of CSF3R mutations can aid in diagnosis, provide prognostic information, and suggest therapeutic options, including JAK inhibitors and other targeted agents. This assay detects clinically relevant mutations in CSF3R, including activating variants in the extracellular domain and truncating variants in the cytoplasmic tail.
Specimen Requirements
Preparation:
PB, BM
Collection:
At least 0.5 ml EDTA, citrate (ACD) or Heparinized whole blood or bone marrow aspirates for DNA mutations
Stability:
96hours/4 to 7 days refrigerated
Unacceptable Conditions:
Specimen submitted is in the incorrect fixative or anticoagulant. Specimen received after the stability date. Gross hemolysis. Frozen specimen. Insufficient specimen. Unlabeled. Left un-refrigerated for an extended period.
Storage & Transport
Blood or bone marrow specimens should be kept at room temperature and preferably received within 96 hrs of drawing. Samples that are 4 to 7 days old should be refrigerated. Sufficient quantity of previously extracted DNA is acceptable if stored at appropriate temperature (short term at 2–8oC or long term at -15 to -25 oC) and should be transported on ice.
CPT(s)
81479
New York Approved
Yes
TAT
5
Requisition Type
Heme
Levels of Service
Full
DexS Code
NONE
Prefix
MI
*The CPT codes provided are for informational purposes only and are based on AMA guidelines The billing party is solely responsible for correct CPT coding.
