MYD88 (WM)
Unique Identifier:
ML-H025
Name on Requisition:
MYD88 (WM)
Product Line:
HEME
Panel Group:
PCR
Methodology
Molecular
PCR
Test Description and clinical significance
Genes
MYD88 (WM)
Disease:
Waldenström macroglobulinemia (WM), diffuse large B-cell lymphoma (DLBCL) and other B-cell malignancies.
MYD88 encodes an adaptor protein involved in Toll-like receptor and interleukin-1 receptor signaling, activating downstream NF-κB pathways. The L265P mutation is the most common pathogenic variant, present in the majority of Waldenström macroglobulinemia (WM) cases and in subsets of diffuse large B-cell lymphoma (DLBCL) and other B-cell malignancies. Detection of MYD88 L265P provides diagnostic and prognostic value and may guide the use of targeted therapies. This assay specifically identifies the L265P mutation in MYD88.
Specimen Requirements
Preparation:
PB, BM
Collection:
At least 0.5 ml EDTA, citrate (ACD) or Heparinized whole blood or bone marrow aspirates for DNA mutations
Stability:
96hours/4 to 7 days refrigerated
Unacceptable Conditions:
Specimen submitted is in the incorrect fixative or anticoagulant. Specimen received after the stability date. Gross hemolysis. Frozen specimen. Insufficient specimen. Unlabeled. Left un-refrigerated for an extended period.
Storage & Transport
Blood or bone marrow specimens should be kept at room temperature and preferably received within 96 hrs of drawing. Samples that are 4 to 7 days old should be refrigerated. Sufficient quantity of previously extracted DNA is acceptable if stored at appropriate temperature (short term at 2–8oC or long term at -15 to -25 oC) and should be transported on ice.
CPT(s)
81305
TAT
5
Requisition Type
Heme
Levels of Service
Full
DexS Code
Z00NX
Prefix
MI
*The CPT codes provided are for informational purposes only and are based on AMA guidelines The billing party is solely responsible for correct CPT coding.
