Pan-Myeloid Multigene Panel DNA & RNA
Unique Identifier:
ML-H031
Name on Requisition:
Myeloid Panel-NGS (DNA&RNA)
Product Line:
HEME
Panel Group:
NGS
Panel Name:
Pan-Myeloid Multigene Panel DNA & RNA
Methodology
Molecular
NGS
Test Description and clinical significance
Genes
ABL1, ALK, ANKRD26, ASXL1, BCL2, BCOR, BRAF, CALR, CBL, CCND1, CEBPA, CREBBP, CSF3R, DDX41, DNMT3A, EGFR, ETV6, EZH2, FGFR1, FGFR2, FLT3, FUS, GATA2, HMGA2, HRAS, IDH1, IDH2, IKZF1, JAK2, KIT, KMT2A, KMT2A-PTD, KRAS, MECOM, MET, MLLT10, MLLT3, MPL, MYBL1, MYD88, MYH11, NF1, NPM1, NRAS, NTRK3, NUP214, NUP98, PDGFRA, PDGFRB, PHF6, PPM1D, PRPF8, PTPN11, RARA, RB1, RBM15, RUNX1, SETBP1, SF3B1, SH2B3, SMC1A, SMC3, SRSF2, STAG2, TCF3, TET2, TFE3, TP53, U2AF1, WT1, ZRSR2
Disease:
acute myeloid leukemia (AML), myelodysplastic syndromes (MDS), myeloproliferative neoplasms (MPN)
Myeloid Neoplasms NGS Panel (DNA & RNA) is a comprehensive next-generation sequencing assay designed to detect genetic alterations relevant to myeloid malignancies. The DNA component identifies single nucleotide variants, small insertions/deletions, and selected copy number alterations across commonly mutated genes in acute myeloid leukemia (AML), myelodysplastic syndromes (MDS), myeloproliferative neoplasms (MPN), and related disorders. The RNA component detects clinically significant gene fusions and rearrangements, including those involving PML-RARA, KMT2A, RUNX1, and others. Together, this assay provides diagnostic, prognostic, and therapeutic insights, supporting risk stratification and eligibility for targeted therapies.
Specimen Requirements
Preparation:
PB, BM
Collection:
At least 0.5 ml EDTA, citrate (ACD) or Heparinized whole blood or bone marrow aspirates for DNA mutations
Stability:
96hours/4 to 7 days refrigerated
Unacceptable Conditions:
Specimen submitted is in the incorrect fixative or anticoagulant. Specimen received after the stability date. Gross hemolysis. Frozen specimen. Insufficient specimen. Unlabeled. Left un-refrigerated for an extended period.
Storage & Transport
Blood or bone marrow specimens should be kept at room temperature and preferably received within 96 hrs of drawing. Samples that are 4 to 7 days old should be refrigerated. Sufficient quantity of previously extracted DNA is acceptable if stored at appropriate temperature (short term at 2–8oC or long term at -15 to -25 oC) and should be transported on ice.
CPT(s)
81455
New York Approved
Yes
TAT
5
Requisition Type
Heme
Levels of Service
Full
DexS Code
Z05C5
Prefix
MI
*The CPT codes provided are for informational purposes only and are based on AMA guidelines The billing party is solely responsible for correct CPT coding.
