CXCR4 (WM)
Unique Identifier:
ML-H029
Name on Requisition:
CXCR4 (WM)
Panel Group:
NGS
Methodology
Molecular
NGS
Test Description and clinical significance
Genes
CXCR4
Disease:
Waldenström macroglobulinemia (WM
CXCR4 encodes a chemokine receptor involved in cell trafficking and survival signaling. Somatic mutations in CXCR4, most often nonsense or frameshift variants in the C-terminal domain, are found in a subset of patients with Waldenström macroglobulinemia (WM). These mutations are associated with disease biology, prognosis, and response to therapy, particularly BTK inhibitors. This assay detects clinically relevant CXCR4 mutations implicated in W
Specimen Requirements
Preparation:
PB, BM
Collection:
At least 0.5 ml EDTA, citrate (ACD) or Heparinized whole blood or bone marrow aspirates for DNA mutations
Stability:
96hours/4 to 7 days refrigerated
Unacceptable Conditions:
Specimen submitted is in the incorrect fixative or anticoagulant. Specimen received after the stability date. Gross hemolysis. Frozen specimen. Insufficient specimen. Unlabeled. Left un-refrigerated for an extended period.
Storage & Transport
Blood or bone marrow specimens should be kept at room temperature and preferably received within 96 hrs of drawing. Samples that are 4 to 7 days old should be refrigerated. Sufficient quantity of previously extracted DNA is acceptable if stored at appropriate temperature (short term at 2–8oC or long term at -15 to -25 oC) and should be transported on ice.
CPT(s)
81479
New York Approved
Yes
TAT
5
Requisition Type
Heme
Levels of Service
Full
DexS Code
NONE
Prefix
MI
*The CPT codes provided are for informational purposes only and are based on AMA guidelines The billing party is solely responsible for correct CPT coding.
