D5S23:D5S721/CSF1R
Methodology
FISH
Test Description and clinical significance
Probes
5p15.2-p15.31/5q32-q33.1
Disease:
myelodysplastic neoplasm and AML
The CSF1R gene is consistently lost by partial deletions occurring in chromosome 5 in patients with myelodysplastic neoplasm (MDS). Specific deletion of the CSFS1R gene has been detected in as many as 40% of MDS patients. helping determine whether there is a complete loss of chromosome 5 versus a 5q deletion (5q-) present in MDS.
NGS MDS panel is recommended
Specimen Requirements
Collection:
1~2ml in Green top (Sodium Heparin) tube OR Lavender top (EDTA) tube/ 10 mL of fluid in RPMI medium, or
1 cm3 marble-sized piece of fresh tumor immersed completely with RPMI medium or sterile saline
Stability:
120 Hours/48 hours
Unacceptable Conditions:
DO NOT FREEZE
Storage & Transport
Room Temperature/Refrigerated (2–8°C )
CPT(s)
88377
New York Approved
YES
TAT
2 Days
*The CPT codes provided are for informational purposes only and are based on AMA guidelines The billing party is solely responsible for correct CPT coding.
