EGFR
Unique Identifier:
ML-S018
Name on Requisition:
EGFR
Product Line:
ST
Panel Group:
Solid Tumor Panels
Panel Name:
EGFR
Methodology
Molecular
NGS
Test Description and clinical significance
Genes
EGFR
Disease:
non-small cell lung carcinoma (NSCLC)
EGFR encodes a receptor tyrosine kinase involved in cell proliferation and survival. Activating mutations, most commonly exon 19 deletions and L858R substitutions in exon 21, are frequent in non-small cell lung carcinoma (NSCLC) and predict response to EGFR tyrosine kinase inhibitors (TKIs). This assay detects clinically relevant EGFR mutations to guide targeted therapy selection and resistance monitoring.
Specimen Requirements
Preparation:
FFPE tissue or slides
Collection:
In case of FFPE sections, 5-10 sections are recommended at 4 to 10 micron.
Stability:
Stored at room temperature
Unacceptable Conditions:
Specimen submitted is in the incorrect fixative. Insufficient specimen (less than 10% of tumor). Bacterial over growth. Submitted with incomplete requisition form (unless a requisition is subsequently sent). Unlabeled or improperly labeled specimens, without contact information or when failing to
reach the ordering physician for clarification. Decalcified specimens. Improperly stored DNA.
Storage & Transport
Store FFPE blocks and slides at room temperature. Slides may be stored at ambient
CPT(s)
81235
New York Approved
Yes
TAT
7
Requisition Type
ST
Levels of Service
Full
DexS Code
PENDING
Prefix
MI
*The CPT codes provided are for informational purposes only and are based on AMA guidelines The billing party is solely responsible for correct CPT coding.
