KRAS
Unique Identifier:
ML-S019
Name on Requisition:
KRAS
Product Line:
ST
Panel Group:
Solid Tumor Panels
Panel Name:
KRAS
Methodology
Molecular
NGS
Test Description and clinical significance
Genes
KRAS
Disease:
colorectal, lung, and pancreatic cancers
KRAS encodes a GTPase that regulates cell signaling through the MAPK and PI3K pathways. Mutations, particularly in codons 12, 13, and 61, are found in colorectal, lung, and pancreatic cancers and predict lack of response to EGFR-targeted therapies. Detection of KRAS mutations provides essential diagnostic and predictive information for therapy selection.
Specimen Requirements
Preparation:
FFPE tissue or slides
Collection:
In case of FFPE sections, 5-10 sections are recommended at 4 to 10 micron.
Stability:
Stored at room temperature
Unacceptable Conditions:
Specimen submitted is in the incorrect fixative. Insufficient specimen (less than 10% of tumor). Bacterial over growth. Submitted with incomplete requisition form (unless a requisition is subsequently sent). Unlabeled or improperly labeled specimens, without contact information or when failing to
reach the ordering physician for clarification. Decalcified specimens. Improperly stored DNA.
Storage & Transport
Store FFPE blocks and slides at room temperature. Slides may be stored at ambient
CPT(s)
81275, 81276
New York Approved
Yes
TAT
7
Requisition Type
ST
Levels of Service
Full
DexS Code
PENDING
Prefix
MI
*The CPT codes provided are for informational purposes only and are based on AMA guidelines The billing party is solely responsible for correct CPT coding.
