BRAF
Unique Identifier:
ML-S020
Name on Requisition:
BRAF
Product Line:
ST
Panel Group:
Solid Tumor Panels
Panel Name:
BRAF
Methodology
Molecular
NGS
Test Description and clinical significance
Genes
BRAF
Disease:
melanoma, colorectal, thyroid, and lung cancers
BRAF encodes a serine/threonine kinase downstream of RAS in the MAPK pathway. The V600E mutation is the most common activating alteration, seen in melanoma, colorectal, thyroid, and lung cancers. Identification of BRAF mutations has diagnostic, prognostic, and therapeutic implications, guiding the use of BRAF and MEK inhibitors in appropriate tumor types.
Specimen Requirements
Preparation:
FFPE tissue or slides
Collection:
In case of FFPE sections, 5-10 sections are recommended at 4 to 10 micron.
Stability:
Stored at room temperature
Unacceptable Conditions:
Specimen submitted is in the incorrect fixative. Insufficient specimen (less than 10% of tumor). Bacterial over growth. Submitted with incomplete requisition form (unless a requisition is subsequently sent). Unlabeled or improperly labeled specimens, without contact information or when failing to
reach the ordering physician for clarification. Decalcified specimens. Improperly stored DNA.
Storage & Transport
Store FFPE blocks and slides at room temperature. Slides may be stored at ambient
CPT(s)
81210
New York Approved
Yes
TAT
7
Requisition Type
ST
Levels of Service
Full
DexS Code
PENDING
Prefix
MI
*The CPT codes provided are for informational purposes only and are based on AMA guidelines The billing party is solely responsible for correct CPT coding.
