NRAS
Unique Identifier:
ML-S021
Name on Requisition:
NRAS
Product Line:
ST
Panel Group:
Solid Tumor Panels
Panel Name:
NRAS
Methodology
Molecular
NGS
Test Description and clinical significance
Genes
NRAS
Disease:
melanoma & colorectal cancers
NRAS encodes a GTP-binding protein that regulates cell proliferation and survival. Mutations in codons 12, 13, and 61 occur in a subset of melanoma, colorectal, and hematologic malignancies. Detection of NRAS mutations provides diagnostic and predictive information, particularly for determining eligibility or resistance to targeted therapies.
Specimen Requirements
Preparation:
FFPE tissue or slides
Collection:
In case of FFPE sections, 5-10 sections are recommended at 4 to 10 micron.
Stability:
Stored at room temperature
Unacceptable Conditions:
Specimen submitted is in the incorrect fixative. Insufficient specimen (less than 10% of tumor). Bacterial over growth. Submitted with incomplete requisition form (unless a requisition is subsequently sent). Unlabeled or improperly labeled specimens, without contact information or when failing to
reach the ordering physician for clarification. Decalcified specimens. Improperly stored DNA.
Storage & Transport
Store FFPE blocks and slides at room temperature. Slides may be stored at ambient
CPT(s)
81311
New York Approved
Yes
TAT
7
Requisition Type
ST
Levels of Service
Full
DexS Code
NONE
Prefix
MI
*The CPT codes provided are for informational purposes only and are based on AMA guidelines The billing party is solely responsible for correct CPT coding.
