NTRK1/2/3
Unique Identifier:
ML-S022
Name on Requisition:
NTRK1/2/3
Product Line:
ST
Panel Group:
Solid Tumor Panels
Panel Name:
NTRK1/2/3
Methodology
Molecular
NGS
Test Description and clinical significance
Genes
NTRK1, NTRK2 & NTRK3
Disease:
All Solid tumors
NTRK1, NTRK2, and NTRK3 encode the tropomyosin receptor kinase (TRK) family of proteins involved in neuronal development and cell signaling. Oncogenic gene fusions involving NTRK1/2/3 occur across a wide spectrum of solid tumors and drive constitutive activation of TRK signaling. Detection of NTRK fusions provides critical diagnostic and therapeutic guidance, identifying patients who may benefit from TRK inhibitor therapy.
Specimen Requirements
Preparation:
FFPE tissue or slides
Collection:
In case of FFPE sections, 5-10 sections are recommended at 4 to 10 micron.
Stability:
Stored at room temperature
Unacceptable Conditions:
Specimen submitted is in the incorrect fixative. Insufficient specimen (less than 10% of tumor). Bacterial over growth. Submitted with incomplete requisition form (unless a requisition is subsequently sent). Unlabeled or improperly labeled specimens, without contact information or when failing to
reach the ordering physician for clarification. Decalcified specimens. Improperly stored DNA.
Storage & Transport
Store FFPE blocks and slides at room temperature. Slides may be stored at ambient
CPT(s)
81194
New York Approved
Yes
TAT
7
Requisition Type
ST
Levels of Service
Full
DexS Code
NONE
Prefix
MI
*The CPT codes provided are for informational purposes only and are based on AMA guidelines The billing party is solely responsible for correct CPT coding.
