PTPRT/20q11
Methodology
FISH
Test Description and clinical significance
Probes
20q11.21/20q12
Disease:
MDS, myeloproliferative neoplasm, melanoma and NSCLC.
Detection of deletions involving the human PTPRT gene ( Protein tyrosine phosphatase receptor type T) as well as the detection of chromosome 20q11 specific sequences. Deletion of long arm of chromosome 20 [del(20q)] is the second most frequent recurrent chromosomal abnormality in hematological malignancies In patients with myelodysplastic neoplasms (MDS), a 20q deletion [del(20q)] isis associated with a favorable prognosis in MDS.
NGS MDS/MPN panel/NGS P.vera reflexes JAK2 V617F reflex to exons 12, 13 &15 are recommended
Specimen Requirements
Collection:
1~2ml in Green top (Sodium Heparin) tube OR Lavender top (EDTA) tube/ 10 mL of fluid in RPMI medium, or
1 cm3 marble-sized piece of fresh tumor immersed completely with RPMI medium or sterile saline
Stability:
120 Hours/48 hours
Unacceptable Conditions:
DO NOT FREEZE
Storage & Transport
Room Temperature/Refrigerated (2–8°C )
CPT(s)
88377
New York Approved
YES
TAT
2 Days
*The CPT codes provided are for informational purposes only and are based on AMA guidelines The billing party is solely responsible for correct CPT coding.
