Genes
AKT1, ALK, AR, ARAF, BRAF, CD274, CDK4, CDKN2A, CHEK2, CNNB1, EGFR, ERBB2, ERBB3, ERBB4, ESR1, FGFR1, FGFR2, FGFR3, FGFR4, FLT3, GNA11, GNAQ, GNAS, HRAS, IDH1, IDH2, KIT, KRAS, MAP2K1, MAP2K2, MET, MTOR, NRAS, NTRK1, NTRK2, NTRK3, PDGFRA, PIK3CA, PTEN, RAF1, RET, ROS1, SMO and TP53

Disease:
Tumor of Unknown Origin (TUO)

The OncoSwift® Tumor of Unknown Origin (TUO) Comprehensive Panel provides broad genomic profiling to aid in the classification of malignancies lacking a defined primary site. It detects mutations, fusions, copy number changes, MSI, and TMB, offering diagnostic clues, prognostic data, and therapy guidance for personalized management.

Preparation:
PB

Collection:
Two tubes of peripheral blood (10mL/tube) are collected in PAXgene Blood ccfDNA tube

Stability:
7 to 10 days at room temperature

Unacceptable Conditions:
Specimen submitted is not in the PAXgene Blood ccfDNA Tubes or n the PAXgene Blood ccfDNA tube after expired date. Insufficient specimen (less than 10 mL whole blood/tube). Specimen is leaking from the collection tube, or the glass tube is broken. Gross hemolysis. Bacterial overgrowth Submitted with incomplete requisition form (unless a requisition is subsequently sent). Unlabeled or improperly labeled specimens, without contact information or when failing to reach the ordering physician for clarification. cfDNA shipped in inappropriate temperature .