Lynch Syndrome & Hereditary Colon Cancer Risk Assessment Panel
Unique Identifier:
ML-N002
Name on Requisition:
Lynch Syndrome & Hereditary Colon Cancer Risk Assessment Panel
Product Line:
NH
Panel Group:
Hereditary Cancer Panels
Panel Name:
Lynch Syndrome & Hereditary Colon Cancer Risk Assessment Panel
Methodology
Molecular
NGS
Test Description and clinical significance
Genes
APC, ATM, AXIN2, BRCA1, BRCA2, BARD1, BMPR1A, BRIP1, CDH1, CHEK2, EPCAM, MLH1, MRE11A, MSH2, MSH3, MSH6, MUTYH, NF1, NTHL1, PALB2, PMS2, POLD1, POLE, PTEN, RAD50, RAD51C, RAD51D, SMAD4, STK11, TP53
Disease:
Lynch Syndrome & Colon Cancer
The Lynch Syndrome & Hereditary Colon Cancer Risk Assessment Panel analyzes germline variants in DNA mismatch repair (MMR) genes—MLH1, MSH2, MSH6, PMS2, and EPCAM—and other colorectal cancer–associated genes. Pathogenic variants confer increased risk for colorectal, endometrial, gastric, and other Lynch-associated cancers. Results provide diagnostic confirmation, enable family risk assessment, and inform preventive and surveillance strategies.
Specimen Requirements
Preparation:
PB, saliva
Collection:
Specimen should contain least 0.5 mL of peripheral blood (lower volumes may be accepted if situation demands), but we prefer larger specimens in case of a low content of nucleated cells. For saliva, it is recommended to request 1.5-2.0 ml of saliva to be collected from each patient.
Stability:
4 to 7 days refrigerated fpr PB and upto 1 year for slaiva at room temperature
Unacceptable Conditions:
Specimen submitted is in the incorrect fixative or anticoagulant. Specimen received after the stability date. Gross hemolysis. Frozen specimen. Insufficient specimen. Unlabeled. Left un-refrigerated for an extended period.
Storage & Transport
4 to 7 days refrigerated fpr PB and upto 1 year for slaiva at room temperature
CPT(s)
81435
New York Approved
Yes
TAT
14-21
Requisition Type
NH
Levels of Service
Full
DexS Code
Z03NY
Prefix
MI
*The CPT codes provided are for informational purposes only and are based on AMA guidelines The billing party is solely responsible for correct CPT coding.
