ETV6
Methodology
FISH
Test Description and clinical significance
Probes
12p13.2
Disease:
myelodysplastic neoplasm, Leukemias (AML,ALL, PDGFRB-associated chronic eosinophilic leukemia), congenital fibrosarcoma
Detection of abnormalities involving the human ETV6 gene at 12p13.2 in by fluorescence in situ hybridization (FISH). The ETV6 gene encodes an ETS family transcriptional repressor and is frequently rearranged or fused with other genes in human leukemias of myeloid or lymphoid origins and MDS.
NGS MDS/MPN panel is recommended
Specimen Requirements
Collection:
1~2ml in Green top (Sodium Heparin) tube OR Lavender top (EDTA) tube/ 10 mL of fluid in RPMI medium, or
1 cm3 marble-sized piece of fresh tumor immersed completely with RPMI medium or sterile saline
Stability:
120 Hours/48 hours
Unacceptable Conditions:
DO NOT FREEZE
Storage & Transport
Room Temperature/Refrigerated (2–8°C )
CPT(s)
88377
New York Approved
YES
TAT
2 Days
*The CPT codes provided are for informational purposes only and are based on AMA guidelines The billing party is solely responsible for correct CPT coding.
