ALK (Lymphoma)
Alternative name:
Anaplastic lymphoma kinase, (2p23)
Methodology
FISH
Test Description and clinical significance
Probes
ALK (2p23)
Disease:
This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma as well as non small cell lung cancer
This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. ALK-positive anaplastic large cell lymphomas have better prognosis
Specimen Requirements
Collection:
1~2ml in Green top (Sodium Heparin) tube OR Lavender top (EDTA) tube.
Stability:
120 Hours
Unacceptable Conditions:
DO NOT FREEZE
Storage & Transport
Room Temperature
CPT(s)
88377
New York Approved
YES
TAT
2 Days
*The CPT codes provided are for informational purposes only and are based on AMA guidelines The billing party is solely responsible for correct CPT coding.
