PLAP

PLAP Alternative Name Placental Alkaline Phosphatase Methodology Immunohistochemistry (IHC) Test Description Probes/Genes PLAP IHC Disease Germ cell neoplasms, seminoma, dysgerminoma, and germinoma of

PMS2

PMS2 Methodology Immunohistochemistry (IHC) Test Description Probes/Genes MSI Disease Colorectal cancersPMS2 is a component of the DNA mismatch repair system/ The PMS2 gene (on chromosome 7) encodes an

PR

PR Alternative Name Progesterone Receptor, PgR Methodology Immunohistochemistry (IHC) Test Description Probes/Genes PR IHC Disease Breast cancerPR belongs to the superfamily of steroid hormone receptors,

PSA

PSA Alternative Name Prostate Specific Antigen Methodology Immunohistochemistry (IHC) Test Description Probes/Genes PSA IHC Disease Prostate cancerMarker of glandular epithelium in normal and neoplastic

PSAP

PSAP Alternative Name Prostate Specific Acid Phosphatase Methodology Immunohistochemistry (IHC) Test Description Probes/Genes PSAP IHC Disease Differentiates between prostatic and urothelial carcinomas/Differentiates

PSMA

PSMA Alternative Name Prostate Specific Membrane Antigen Methodology Immunohistochemistry (IHC) Test Description Probes/Genes PSMA IHC Disease Metastatic prostate carcinomaType II transmembrane glycoprotein

RCC

RCC Alternative Name Renal Cell Carcinoma 1 Methodology Immunohistochemistry (IHC) Test Description Probes/Genes RCC IHC Disease Renal cell carcinomaAnti renal cell carcinoma (RCC) antibodies detect a

Reticulin

Reticulin Alternative Name Reticular Nuclear Fast Red Stain Methodology Special Stains Test Description Probes/Genes RETIC SS Disease Outlines architecture of liver and spleen,hemangiopericytoma, vascular

S-100

S-100 Methodology Immunohistochemistry (IHC) Test Description Probes/Genes S100 IHC Disease Marker of schwann cells and melanocyte, nerve sheath tumors, melanoma, and Langerhans cell histiocytosisFamily

SMMS-1

SMMS-1 Alternative Name Smooth Muscle Myosin, Heavy Chain, SMMHC Methodology Immunohistochemistry (IHC) Test Description Probes/Genes SMMS IHC Disease Distinguish benign breast lesions and carcinoma in

SOX-10

SOX-10 Methodology Immunohistochemistry (IHC) Test Description Probes/Genes SOX-10 IHC Disease Melanoma marker, soft tissue tumors of neural crest originTranscription factor known to be crucial in the

SOX11

SOX11 Methodology Immunohistochemistry (IHC) Test Description Probes/Genes SOX11 IHC Disease Mantle cell lymphomaSOX11 is a transcription factor that is normally expressed in the fetal brain and has also

STAT6

STAT6 Methodology Immunohistochemistry (IHC) Test Description Probes/Genes stat6 IHC Disease Distinction of solitary fibrous tumorSignal transducer and activator of transcription (STAT) 6/Member of STAT

Synaptophysin

Synaptophysin Methodology Immunohistochemistry (IHC) Test Description Probes/Genes SYNAPT IHC Disease Identification of neuronal tumors and tumors with neuroendocrine differentiationA protein (38 kD),

TdT

TdT Methodology Immunohistochemistry (IHC) Test Description Probes/Genes TDT IHC Disease Differentiating precursor lymphoid neoplasms, from other small blue cell tumors. Identifying clusters of thymocytes

Thrombomodulin (TM)

Thrombomodulin (TM) Methodology Immunohistochemistry (IHC) Test Description Probes/Genes THROM IHC Disease Mesothelioma, Squamous Cell Carcinoma, Urothelial Carcinoma.Also called CD141. Thrombomodulin

Thyroglobulin (TGB)

Thyroglobulin (TGB) Methodology Immunohistochemistry (IHC) Test Description Probes/Genes THYRO IHC Disease Classification of thyroid carcinomaLarge glycoprotein (MW 670K) produced by thyroid follicular

TIA-1

TIA-1 Alternative Name T-cell Intracytoplasmic Antigen Methodology Immunohistochemistry (IHC) Test Description Probes/Genes TIA1 IHC Disease Neoplasms of cytotoxic T cells or natural killer cellsTIA-I

TRAP

TRAP Alternative Name Tartrate Resistant Acid Phosphatase Methodology Immunohistochemistry (IHC) Test Description Probes/Genes TRAP IHC Disease Hairy cell leukemia, mantle cell lymphoma, splenic marginal

Trichrome

Trichrome Methodology Special Stains Test Description Probes/Genes TRI SS Disease Collagen and smooth muscle in tumors, cirrhosisStains collagen blue

TTF-1

TTF-1 Alternative Name Thyroid Transcription Factor Methodology Immunohistochemistry (IHC) Test Description Probes/Genes TTF1 IHC Disease Distinguish primary and metastatic lung carcinoma from non lung

Tyrosinase

Uroplakin II

Uroplakin II Methodology Immunohistochemistry (IHC) Test Description Probes/Genes UROPII IHC Disease Urothelial lesions/Ovarian Brenner tumorTransmembrane protein expressed by urothelial lining cells (umbrella

Uroplakin III

Uroplakin III Methodology Immunohistochemistry (IHC) Test Description Probes/Genes UROPIII IHC Disease Urothelial lesions/Ovarian Brenner tumorTransmembrane protein expressed by urothelial lining cells

Vimentin

Vimentin Methodology Immunohistochemistry (IHC) Test Description Probes/Genes VIMENT IHC Disease fibrosarcomas, liposarcomas, malignant fibrous histocytomas, angiosarcomas, chondrosarcomas and lymphomasVimentin